Mutations in NPC1L1 and coronary heart disease.

n engl j med 372;9 nejm.org february 26, 2015 881 between lower thresholds for glycated hemoglobin (as well as albuminuria and possibly other variables of interest) and adverse cardiovascular events were beyond the scope of our study, we agree that such investigations would be valuable and should be pursued in future studies. In response to Magliano et al.: we agree that the proportion of deaths due to cardiovascular disease in our study is likely to be an underestimation and that cardiovascular disease probably contributed to a fair share of the deaths categorized as having diabetes as the underlying cause. However, because many of the deaths due to diabetes had multiple or unspecified complications (including cardiovascular disease), and furthermore, because we were not able to validate the final chain of events leading to death from the data in the register, we used a conservative approach. Marcus Lind, M.D., Ph.D.